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Any discrepancies in the extracted data were resolved by consensus through discussion between the two reviewers or resolved by a third researcher (XM)

intravenous TB-4 Phase 1 safety and pharmacokinetics, no dose-limiting or serious adverse events (Ann N Y Acad Sci 2010;1194:223229): NCT00743769 Centers for Disease Control and Prevention

the flow rate of the first and second purification depends on the size of the RP-HPLC preparation column

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Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline